Table 1.

Key functions of individual tetraspanins on immune cell subsets.

Tetraspanin	Function on immune cells
CD37	− T cell proliferation, peptide MHC presentation, antibody production, IL-6 signaling by B cells
	+ Dendritic cell (DC) migration, B cell survival
CD53	+ B cell receptor-dependent protein kinase C signaling
	− IL-6, TNFα production
Tssc6	− T cell proliferation
CD9	− TNF-α production
	+ MHC class II trafficking
CD81	− T cell proliferation, TNF-α production
	+ DC motility, immunological synapse organization, Th2 response, antibody production
CD82	− DC migration
	+ DC–T cell conjugation
	+ Antigen presentation
CD151	− T cell proliferation, T cell motility, co-stimulation in DCs
CD63	− exosome secretion

−, inhibits; +, stimulates.