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. 2018 May 29;9:1179. doi: 10.3389/fimmu.2018.01179

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Copyright © 2018 Chen, Chen, Liu, Que, Zhang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression and prognostic significance of IL-33 and ST2 in soft tissue sarcoma. (A) The expression of IL-33 and ST2 in tumor tissues was lower than those in adjacent normal tissues. A total of 18 pairs of sarcoma and adjacent normal tissue specimens were collected and used for real-time PCR assays for IL-33 and ST2 expression. The expression data were normalized to the geometric mean of the housekeeping gene β-actin. *P < 0.05, **P < 0.01 using paired t-test. (B) Higher transcriptional levels of IL-33 and ST2 were associated with a better outcome. Transcriptional sequencing and survival data from patients with soft tissue sarcoma were obtained from the publicly accessible The Cancer Genome Atlas portal, and overall survival analysis was evaluated by Kaplan–Meier and Log-rank test.