Table 2.

The list of oxalate degrading pathways according to MetaCyc. The potential presence (+) or absence (-) of oxalate degradation pathways is shown in the respective Paraburkholderia terrae strains. Cupin domain containing proteins are postulated to be acting either as oxalate oxidase or oxalate decarboxylase.

Strains	Pathway I(a)	Pathway II(b)	Pathway III(c)	Pathway IV(d)	Pathway V(e)
Paraburkholderia terrae BS001	-	+	+	±	±
Paraburkholderia terrae BS110	-	+	+	±	±
Paraburkholderia terrae BS007	-	+	+	±	±
Paraburkholderia terrae BS437	-	+	+	±	±
Paraburkholderia terrae DSM 17804T	N/A	N/A	N/A	N/A	N/A

N/A, not applicable, as genome information not available at the time of writing. “+” indicates presence, “-” indicates absence, and “±” presence or absence (cupin domain containing proteins; described down the line). ^(a)Single reaction pathway that involves the direction conversion of oxalate to two CO2 molecules that is catalyzed by oxalate oxidoreductase in the presence of two oxidized ferredoxin [iron–sulfur] cluster. ^(b)Consists of three reactions resulting in the conversion of oxalate to formate, involving oxalate CoA–transferase, oxalyl–CoA decarboxylase, and formyl–CoA transferase. ^(c)The third pathway concerning oxalate degradation has two possible outcomes, where oxalyl–CoA is either converted to formate and subsequently to NADH or to glyoxalate that goes to glycolate and glyoxalate degradation pathway. ^(d)The fourth pathway involves only one reaction where oxalate is converted to hydrogen peroxide via oxalate oxidase. ^(e)The fifth pathway involves only one reaction where oxalate is converted to formate via oxalate decarboxylase. Cupin: either acting as oxalate oxidase (monocupin) or oxalate decarboxylase (bicupin; Tanner et al., 2001). Based on the presence of cupin in the genomes of P. terrae strains, they are proposed to have roles in oxalate degradation.