Table 1.
Demographic, clinical data, and head motion of patients with OCD.
| Variable | Patients | ASD | Non-ASD | |||||
|---|---|---|---|---|---|---|---|---|
| N (%) | Mean (SD) | Range | N (%) | Mean (SD) | N (%) | Mean (SD) | P-value | |
| Age (years) | 32.8 (7.7) | 18–48 | 31.5 (8.2) | 33.7 (7.5) | 0.298 | |||
| Gender (male/female) | 12/21 | 9/4 | 5/15 | 0.029*† | ||||
| Handedness (right/left) | 33/0 | 13/0 | 20/0 | – | ||||
| Age of onset of OCD (years) | 22.4 (8.1) | 6–40 | 20.9 (6.5) | 23.4 (9.1) | 0.465 | |||
| Duration of illness (years) | 10.4 (7.7) | 0–25 | 10.8 (7.7) | 10.1 (7.9) | 0.917 | |||
| Y-BOCS | 26.2 (3.5) | 19–34 | 27.1 (3.1) | 25.6 (3.7) | 0.372 | |||
| AQ | 25.1 (6.8) | 10–39 | 28.5 (4.8) | 23.0 (7.1) | 0.005* | |||
| BDI | 18.2 (11.0) | 2–44 | 23.9 (6.2) | 15.1 (12.0) | 0.011* | |||
| FIQ | 102.2 (11.4) | 80–122 | 103.2 (9.9) | 101.5 (12.5) | 0.624 | |||
| Comorbidities | ||||||||
| Major depressive disorder | 4 (12) | 3 (23) | 3 (15) | 0.659† | ||||
| Social anxiety disorder | 2 (6) | 1 (8) | 1 (5) | 1.000† | ||||
| Generalized anxiety disorder | 1 (3) | 0 | 1 (5) | – | ||||
| Bulimia | 1 (3) | 0 | 1 (5) | – | ||||
| Agoraphobia | 1 (3) | 0 | 1 (5) | – | ||||
| Medication at time of study | ||||||||
| Medication-free | 9 (27) | 4 (31) | 5 (25) | 1.000† | ||||
| SSRIs | 13 (39) | 4 (31) | 9 (45) | 0.485† | ||||
| Antipsychotic augmentations | 6 (18) | 4 (31) | 2 (10) | 0.182† | ||||
| Major tranquilizers | 4 (12) | 0 | 4 (20) | – | ||||
| Clomipramine | 1 (3) | 2 (15) | 0 | – | ||||
| Head motion | ||||||||
| Translation (mm) | 0.773 (0.261) | 0.880 (0.288) | 0.563 (0.115) | 0.057 | ||||
| Rotation (degrees) | 0.005 (0.003) | 0.006 (0.003) | 0.004 (0.001) | 0.049* | ||||
SD, standard deviation; OCD, obsessive-compulsive disorder; Y-BOCS, Yale-Brown Obsessive-Compulsive Scale; AQ, Autism Spectrum Quotient; BDI, Beck Depression Inventory; FIQ, Full scale Intelligence Quotient assessed by WAIS-III, SSRIs, selective serotonin reuptake inhibitors; SSRIs, number of patients taking only SSRIs; Antipsychotic augmentations, number of patients taking both SSRIs and major tranquilizers; Major tranquilizer, number of patients taking only major tranquilizers; Mean of chlorpromazine equivalent of major tranquilizers for each patient (92.7 ± 65.6 mg). Mean of imipramine equivalent of antidepressants for each patient (138.4 ± 65.1 mg).
p < 0.05,
Fisher's exact test.