Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 29;12:359. doi: 10.3389/fnins.2018.00359

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Albert and Huttner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Polycomb-mediated histone methylation during mouse neocortex development. During the development of the mouse neocortex, neural progenitor cells pass through consecutive stages of expansion, neurogenesis, and gliogenesis (top scheme). aRG undergoing neurogenic divisions give rise to bIPs, which are the main source of neurons in the mouse. As neural progenitor cells transition from proliferation to neurogenic divisions, their histone methylation profiles change dynamically. Whereas, many genes are in a bivalent configuration in early proliferative progenitor cells, many of these poised domains are resolved with progressive lineage commitment. The gene ontology categories characteristic of the genes marked by H3K27me3 (red) or bivalent modifications (yellow) during early neurogenesis and in neurons are indicated (bottom scheme). In addition, the core components of Polycomb repressive complex 1 (PRC1) and 2 (PRC2) are shown. VZ, ventricular zone; SVZ, subventricular zone; IZ, intermediate zone; CP, cortical plate; DL, deep-layer; UL, upper-layer.