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. 2018 Apr 5;26(6):1494–1508. doi: 10.1016/j.ymthe.2018.04.002

Figure 6.

Figure 6

The Wnt/β-Catenin Signaling Pathway Mediates CILA1-Induced Chemoresistant TSCC Cell Anti-apoptosis and Proliferation

(A) TUNEL analysis showed that the silencing of CILA1 expression impaired the TSCC anti-apoptotic abilities induced by cisplatin, while CHIR 99021 reversed this effect. (B) The percentage of apoptotic cells was determined by flow cytometry, and CILA1 inhibition enhanced TSCC cell apoptosis induced by cisplatin, while CHIR99021 partially attenuated this effect. (C) Knockdown of CILA1 impaired the TSCC cell growth rate upon cisplatin treatment, as determined by an MTS assay, while CHIR99021 rescued TSCC cell proliferation (**p < 0.01; ***p < 0.001).