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. 2018 May 29;9:546. doi: 10.3389/fphar.2018.00546

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Copyright © 2018 Donoso, Mascayano, Poblete and Huidobro-Toro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time course of ATP and related purines detected in the rat arterial mesenteric bed perfusate upon EFS of the tissue nerve terminals in endothelium-denuded preparations. Perfusate aliquots from the rat arterial mesenteric vasculature were collected to assay ATP and related purine metabolites before, during, and after EFS (symbolized as the 1 min 20 Hz stimulation bar) of the tissue’s perivascular nerve terminals. (A) ATP, (B) ADP, (C) AMP, and (D) ADO. Gray columns indicate vehicle-treated controls (n = 10); open columns correspond to STZ-treated rats (n = 19). Columns indicate the mean average values of ATP and purine metabolites along the time course protocol; bars indicate the SEM.^∗p < 0.05; ^∗∗p < 0.01, and ^∗∗∗p < 0.001, in case an ADP, unpaired Student’s t-test was applied, ATP, AMP, and ADO applied Mann–Whitney test as compared to matched control at the several times.