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The administration of rh-MANF significantly decreased the number of Caspase-3 and NeuN double-stained cells at 24 h after ICH, which could be obviously reversed by MK2206 (100 μg). (A) MANF; (B) p-Akt; (C) p-MDM2; (D) Caspase-3; (E) Bcl-2 and Bax. n = 6 for each group. The bars represent the mean ± SD. ∗p < 0.05 vs. sham, #p < 0.05 vs. ICH+ vehicle, &p < 0.05 vs. ICH+ rh-MANF.
