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Development of a Second-Generation Dihalogenation
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| entry | conditions | 17a + iso-17a (% yield) |
17a : iso-17a (cr) |
17a, iso-17a (% ee) |
| 1 | 50 mol % 12, CH2Cl2, r.t. | 88 | 1 : 2 | 6, 8 |
| 2 | 50 mol % 18, CH2Cl2, r.t. | 67 | 1 : 1 | 63, 6 |
| 3 | 50 mol % 18, hexanes, r.t. | 70 | 8 : 1 | 94, 52 |
| 4 | 10 mol % 18, hexanes, −20 °C | 88 | >20 : 1 | 94, − |
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