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. 2018 May 29;12:367. doi: 10.3389/fnins.2018.00367

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Copyright © 2018 Zhang, Ge, Yin, Cui, Zhao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of PFC-BLA-CeA circuitry. The PFC transmits the sensory information to the BLA via amounts of glutamatergic projections. Subsequently, the glutamatergic BLA neurons directly project to the CeA or indirectly via GABAergic interneurons of ITCs. The PFC can affect BLA GABAergic system via regulating DRN 5-HT neurons under stress conditions. Projections from CeA mainly target to regions and brain circuits involved in physiological and behavioral responses to stress glu-ergic, glutamatergic.