Table 1.

PrEPX study timeline, 2013–2019.

Phase	Date	Activity
Pre-PrEPX	2013–2014	Community advocacy for PrEP access and forums held by VAC to discuss PrEP, PrEP stigma and future clinical trials.
	Jun 2014–Dec 2016	VicPrEP study−30 month demonstration project enrolled 114 participants across four sites in Melbourne.
	Jun–Aug 2015	PrEP'D for Change and PrEPaccessNOW formed. General practitioners developed guidelines for prescribing off-label PrEP.
	Dec 2015	Victorian PrEP Accord was signed. Signatories include VAC, LPV, PrEP'DforChange, PrEPaccessNOW, time4PrEp, VicPrEP.
PrEPX planning	Sep-Dec 2015	Approached clinics and community pharmacies to participate in the PrEPX study. Approached peak organizations including VAC, LPV, VACCHO, Centre for Culture, Ethnicity and Health.
	29 Jan 2016	Funding announced by the Victorian DHHS, Alfred Health and VAC for 2,600 places in PrEPX study.
	30 Jan 2016	Study registration opened using REDCap on the Alfred hospital website. Data collected: name, contact details, preferred clinic to attend for PrEPX, whether participant was on PrEP.
	22 Jul 2016	2049 people registered interest on online formClinics provided with partially de-identified list from registration form to enable workforce planning when study openedRegistered individuals emailed about study opening dates and booking information for their preferred clinic.
PrEPX study period	26 Jul 2016	PrEPX enrolment began (wave one of study enrolment) 2600 places opened, 150 of these reserved for priority populations including people who inject drugs and/or people in serodiscordant heterosexual partnerships with high or medium risk for HIV acquisition as per PrEP prescribing guidelines (Table 2).
	14 Oct 2016	PrEPX study neared enrolment capacityStudy enrolment stopped at 2200 participants to allow for people who had booked an appointment and not yet attended to join the study, with other places reserved for priority populations.First waitlist was opened, pending further funding.
	17 Jan 2017	Additional 600 places in PrEPX announced, funded by VAC.
	19 Jan 2017	Additional places released (wave two of study enrolment)All 575 people registered on the waitlist were provided a study place. Clinics were provided a list of participants as per original PrEP enrolment.
	20 Jan 2017	Waitlist was reopened.
	28 Mar 2017	Additional 600 places announced, funded by Victorian DHHS.
	29 Mar 2017	Additional places released (wave three study enrolment)All 617 people registered on the waitlist were provided a study place Clinics were provided list of participants as per original PrEP enrolment.
	30 Mar 2017	Waitlist was reopenedWaitlist remains open November 27th 2017.
	30 June 2019	PrEP-X study estimated end date.

VicPrEP, Victorian PrEP demonstration study; PrEPX, Victorian PrEP population level study; PrEPX-SA, expansion of PrEPX study to South Australia; VAC, Victorian AIDS Council, LPV, Living Positive Victoria; VACCHO, Victorian Aboriginal Community Controlled Health Organisation Inc.; DHHS, Department of Health and Human Services.