Figure 2.

Systemic effects of Porcupine inhibitors. (A) Body weight changes over the study by treatment group (LGK low: LGK974 at 3 mg/kg/day; LGK high: LGK974 at 6 mg/kg/kg/day; C59: Wnt-C59). (B) Femur length at necropsy. (C) Total body bone mineral density (BMD) at necropsy. (D) Spine BMD at necropsy. (G) Serum levels of amino pro-peptide of type 1 collagen (P1NP) and C-terminal type I collagen fragments (CTX) at day 7. ^§These results are obtained from a separate experiment with vehicle and LGK974 at 4.5 mg/kg/day. (E) Serum levels of P1NP and CTX at necropsy in animals treated with vehicle or LKG974 at 6 mg/kg/day. For each graph, n = 10 animals per group. Bars represent the mean and error bars represent the 95% CI of the mean. P values are indicated as *P < 0.05; **P < 0.01; ***P < 0.001.