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Cortical bone effects of LGK974. (A) 3D reconstruction of 50 axial sections from the femur midshaft of a representative animal treated with vehicle or LKG974 at 6 mg/kg/day (Bar: 200 µm). (B) Confocal microscopy images of the periosteal surface of the femur midshaft showing double labeling by calcein (green) 8 days before necropsy and by alizarin (red) 1 day before necropsy as a marker of new bone formation (Bar: 100 µm).
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