Table 2.

Microarchitecture of the trabecular bone.

	Vehicle			Low-dose LGK974				High-dose LGK974				Wnt-C59
	Mean	Lower 95% CI	Upper 95% CI	Mean	Lower 95% CI	Upper 95% CI	P	Mean	Lower 95% CI	Upper 95% CI	P	Mean	Lower 95% CI	Upper 95% CI	P
Metaphyseal distal femur
Trabecular thickness (µm)	48	46	50	46	44	48	0.247	46	44	49	0.468	47	46	48	0.888
Trabecular number (/mm)	4.6	4.3	4.9	3.6	3.3	3.8	<0.001	3.4	3.1	3.6	<0.001	3.9	3.6	4.1	<0.001
Trabecular separation (µm)	118	116	120	123	121	125	0.002	123	122	125	<0.001	122	120	124	0.006
L5 vertebral body
Trabecular thickness (µm)	43	42	45	40	37	43	0.083	38	35	41	0.001	42	40	44	0.505
Trabecular number (/mm)	5.4	5.2	5.7	4.1	3.7	4.5	<0.001	3.8	3.4	4.2	<0.001	4.6	4.4	4.8	<0.001
Trabecular separation (µm)	137	131	142	160	151	169	<0.001	165	158	173	<0.001	153	146	159	0.004

Microarchitecture parameters of trabecular bone at the metaphyseal distal femur and L5 vertebral body analyzed by µCT. Results represent the mean of the n = 10 animals per treatment group with 95% CI and P value.