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. 2018 May 29;10:155. doi: 10.3389/fnagi.2018.00155

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Copyright © 2018 Huentelman, Piras, Siniard, De Both, Richholt, Balak, Jamshidi, Bigio, Weintraub, Loyer, Mesulam, Geula and Rogalski for The Alzheimer’s Disease Neuroimaging Initiative.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manhattan plots showing the results of the Sequence Kernel Association Combined (SKAT-C) analysis between SuperAgers and Alzheimer’s disease neuroimaging initiative (ADNI) controls, without covariates (A) and with covariates (B) included in the model. The red line indicates the significance threshold after Bonferroni correction (p = 3.09E-06), whereas the blue line indicates the nominal significance threshold (p = 0.05). (C) Allele frequencies for the single nucleotidepolymorphisms (SNPs) in the Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) gene in SuperAging, Control and ExAC cohorts (European non-Finnish population sample).