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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Vision Res. 2017 Aug 2;139:153–160. doi: 10.1016/j.visres.2017.03.006

Table 1.

Ingenuity Canonical Pathways −log(p-value) Ratio z-score
Acute Phase Response Signaling 2.85E+01 3.00E-01 1.177
LXR/RXR Activation 2.42E+01 3.20E-01 −1.718
Coagulation System 2.28E+01 6.57E-01 −0.209
Intrinsic Prothrombin Activation Pathway 2.23E+01 7.24E-01 0.229
Complement System 2.20E+01 6.22E-01 −0.5
FXR/RXR Activation 1.92E+01 2.72E-01 NaN
Protein Ubiquitination Pathway 1.31E+01 1.63E-01 NaN
Extrinsic Prothrombin Activation Pathway 1.23E+01 6.67E-01 NaN
Autophagy 6.27E+00 2.32E-01 NaN
NRF2-mediated Oxidative Stress Response 5.64E+00 1.26E-01 3.742
Phagosome maturation 5.58E+00 1.42E-01 NaN
Clathrin-mediated Endocytosis Signaling 5.29E+00 1.21E-01 NaN
IL-12 Signaling and Production in Macrophages 5.25E+00 1.35E-01 NaN
IGF-1 Signaling 4.83E+00 1.48E-01 NaN
Inhibition of Matrix Metalloproteases 4.50E+00 2.31E-01 NaN
Production of Nitric Oxide and ROS in Macrophages 4.34E+00 1.11E-01 −1.279
HIPPO signaling 4.13E+00 1.51E-01 −3.464
Agranulocyte Adhesion and Diapedesis 3.67E+00 1.08E-01 NaN
RhoGDI Signaling 3.61E+00 1.07E-01 0.943
Hypoxia Signaling in the Cardiovascular System 3.48E+00 1.59E-01 NaN
Unfolded protein response 3.41E+00 1.70E-01 NaN
Myc Mediated Apoptosis Signaling 3.11E+00 1.43E-01 NaN
Antigen Presentation Pathway 3.06E+00 1.89E-01 NaN
Granulocyte Adhesion and Diapedesis 3.05E+00 1.02E-01 NaN
Cell Cycle: G2/M DNA Damage Checkpoint Regulation 2.97E+00 1.63E-01 1.342
PI3K/AKT Signaling 2.95E+00 1.10E-01 1.604
Actin Cytoskeleton Signaling 2.73E+00 8.85E-02 0.728
Remodeling of Epithelial Adherens Junctions 2.70E+00 1.36E-01 2
p70S6K Signaling 2.66E+00 1.03E-01 −1.89
Regulation of Cellular Mechanics by Calpain Protease 2.59E+00 1.43E-01 1
Axonal Guidance Signaling 2.46E+00 7.16E-02 NaN
ILK Signaling 2.36E+00 8.76E-02 0
Leukocyte Extravasation Signaling 2.35E+00 8.53E-02 0.258
ERK5 Signaling 2.23E+00 1.25E-01 NaN
VDR/RXR Activation 2.21E+00 1.15E-01 NaN
14-3-3-mediated Signaling 1.96E+00 9.16E-02 2.646
Endoplasmic Reticulum Stress Pathway 1.95E+00 1.90E-01 NaN
Wnt/Beta-catenin Signaling 1.88E+00 8.38E-02 −0.707
Antioxidant Action of Vitamin C 1.83E+00 9.52E-02 0.378
Role of Tissue Factor in Cancer 1.82E+00 9.09E-02 NaN
RhoA Signaling 1.79E+00 9.02E-02 1
Mitotic Roles of Polo-Like Kinase 1.74E+00 1.11E-01 NaN
Lipid Antigen Presentation by CD1 1.74E+00 1.67E-01 NaN
Tumoricidal Function of Hepatic Natural Killer Cells 1.74E+00 1.67E-01 NaN
Aldosterone Signaling in Epithelial Cells 1.72E+00 8.00E-02 NaN
LPS/IL-1 Mediated Inhibition of RXR Function 1.66E+00 7.51E-02 −0.816
Epithelial Adherens Junction Signaling 1.64E+00 8.28E-02 NaN
Semaphorin Signaling in Neurons 1.63E+00 1.15E-01 NaN
Dendritic Cell Maturation 1.57E+00 7.65E-02 1.069