REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-BRD9	Bethyl	Cat# A303-781A RRID:AB_11218396
Rabbit polyclonal anti-VDR	Santa Cruz	Cat# sc-1008 RRID:AB_632070
Mouse monoclonal anti-VDR	Santa Cruz	Cat# sc-13133 RRID:AB_628040
Mouse monoclonal anti-FLAG	Sigma	Cat# P2983 RRID:AB_439685
Rat polyclonal anti HA	Roche	Cat# 11867423001 RRID:AB_390918
Rabbit polyclonal anti-lysine acetylation	Cell Signaling	Cat# 9441S RRID:AB_331805
Rabbit polyclonal anti-GST	Cell Signaling	Cat# 2622 RRID:AB_331670
Rabbit polyclonal anti-PCAF	Cell Signaling	Cat# 3378S RRID:AB_2128409
Rabbit polyclonal anti-SMARCC1/2	Cell Signaling	Cat# 11956
Rabbit polyclonal anti-BRG1	Cell Signaling	Cat# 3508S RRID:AB_2193944
Rabbit polyclonal anti-PBRM1	Bethyl	Cat# A301-591A RRID:AB_1078808
Rabbit polyclonal anti-PHF10	Genetex	Cat# GTX116314 RRID:AB_11176023
Rabbit polyclonal anti-ARID1B	Bethyl	Cat# A301-040A RRID:AB_817895
Rabbit polyclonal anti-HDAC3	Cell Signaling	Cat# 2632 RRID:AB_331545
Rabbit polyclonal anti-IKBa	Cell Signaling	Cat# 4814 RRID:AB_390781
Rabbit polyclonal anti-p65	Cell Signaling	Cat# 8242 RRID:AB_10859369
Rabbit polyclonal anti-IKKb	Cell Signaling	Cat# 8943 RRID:AB_11024092
Mouse monoclonal anti-a Tubulin	EMD	Cat# CP06-100UG RRID:AB_212802
Rabbit polyclonal anti-H3K27Ac	Abcam	Cat# ab4729 RRID:AB_2118291
Rabbit polyclonal anti-Nkx6-1	Cell Signaling	Cat# 54551
Mouse monoclonal anti-glucagon	Abcam	Cat# ab82270 RRID:AB_1658481
Guinea pig polyclonal anti-insulin	Abcam	Cat# ab7842 RRID:AB_306130
Mouse monoclonal anti-proinsulin	R&D	Cat# MAB13361 RRID:AB_2126534
Rabbit polyclonal anti-Ki67	Abcam	Cat# ab16667 RRID:AB_302459
Rabbit polyclonal anti-Calnexin	Cell Signaling	Cat# 2433S RRID:AB_2243887
Rabbit monoclonal anti-PERK	Cell Signaling	Cat# 3192 RRID:AB_2095847
Rabbit polyclonal anti-MAFA	Novus	Cat# NB400-137 RRID:AB_10002142
Rabbit monocolonal anti-phospho-PERK	Cell Signaling	Cat# 3179S RRID:AB_2095853
Biological Samples
Human islets	See Table S1
Chemicals, Peptides, and Recombinant Proteins
Calcipotriol	Tocris	Cat#2700
i-BRD9	R&D	Cat#5591
IL-1b (mouse)	Peprotech	Cat#211-11b
IL-1b (human)	Peprotech	Cat#200-01b
IL-23	Peprotech	Cat#200-23
IL-24	Peprotech	Cat#200-35
IFN-g	Peprotech	Cat#315-05
Streptozotocin	Sigma	S0130
Activin	R&D	338-AC
Wnt3a	R&D	5036-WN
Dorsomophin	Biovision	1656-d
Retinoic acid	Sigma	R2625
SB431542	Sigma	S4317
B27	Gibco	17504-044
Forskolin	Sigma	F3886
Dexmethasone	Sigma	D4904
Alk5 inhibitor II	Calbiochem	616452
Nicotinamide	Sigma	72340
Triiodo-L-thyronine sodium salt (T3)	Sigma	T6397
Doxycycline	Cayman	14422-10
SAHA	Cayman	10009929-100
2-Hydroxypropyl-β Cyclodextrin	Sigma	H-107
Collagenase P	Roche	11213873001
Histopaque-1077	Sigma	H8889
Dynabeads protein A	Life technologies	10002D
Dynabeads protein G	Life technologies	10004D
Recombinant full length His-VDR (SF9 origin)	Life Technologies	12025H08B25
Recombinnat BRD9 bromodomain GST tagged	BPS biosciences	31091
EDTA free protease inhibitor cocktail	Roche	11836170001
Dynabeads Co-Immunoprecipitation Kit	Life Technologies	14321D
Critical Commercial Assays
Mouse insulin ELISA	Millipore	EZRMI-13K
Human insulin ELISA	Millipore	EZHI-14K
Vectastain ABC kit	Vector lab	PK-6101
Annexin V	Ebioscience	88-8088-74
Mouse proinsulin ELISA	Mercodia	NC9088881
Deposited Data
RNA-seq, ChIP-seq and ATAC-seq	This study
Experimental Models: Cell Lines
INS-1	AddexBio	C0018007
HEK-293T	ATCC	CRL-11268
HUVEC-iPS	Yoshihara et. al., 2016	N/A
Experimental Models: Organisms/Strains
Mouse: B6.129S4-Vdrtm1Mbd/J	The Jackson Laboratory	Stock No. 006133
Mouse: B6.BKS(D)-Leprdb/J	The Jackson Laboratory	Stock No. 000697
Mouse: BKS.Cg-Dock7m +/+ Leprdb/J	The Jackson Laboratory	Stock No. 000642
Mouse: C57BL6/J	The Jackson Laboratory	Stock No. 000664
Mouse: FVB/N-Tg(Ins2-IAPP)RHFSoel/J	The Jackson Laboratory	Stock No. 008232
Oligonucleotides
qPCR primers: See Table S2	See Table S2	N/A
siRNA: VDR	GE Healthcare	L-097753-02-0005
siRNA: PCAF	GE Healthcare	L-085879-02-0005
siRNA: BAF180	GE Healthcare	L-088113-02-0005
siRNA: non-targeting pool	GE Healthcare	D-001810-10-05
Recombinant DNA
Lentiviral sgRNA library	Wang et. al., 2014;	Addgene: 51048
Plasmid: pCW-Cas9	Wang et. al., 2014;	Addgene: 50661
Plasmid: human insulin promoter-GFP	Yoshihara et al. 2016	N/A
Plasmid: Lv-VDR-HA	This study	N/A
Plasmid: Lv-BRD9-Flag	This study	N/A
Plasmid: LV-VDR-K91R-HA	This study	N/A
Plasmid: Lv-VDR-K91A-HA	This study	N/A
Plasmid: Lv-BRD7-Flag	This study	N/A
Plasmid: pMSCVpuro-Gcn5(D608A) (PCAF)	Jin et. al., 2014	Addgene: 63707
Plasmid: pMSCVpuro-Gcn5 (PCAF)	Jin et. al., 2014	Addgene: 63705
Plasmid: pCMV-p300-myc	N/A	Addgene: 30489
Software and Algorithms
Homer	N/A	http://homer.ucsd.edu/homer/
CASAVA-1.8.2	Illumina	https://www.illumina.com/
Metascape	N/A	metascape.org
DAVID	N/A	https://david.ncifcrf.gov/
MAGECK	N/A	https://sourceforge.net/projects/mageck/
STAR	N/A	https://github.com/alexdobin/STAR
Fiji	N/A	https://fiji.sc/