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. 2018 May 22;2018:5389282. doi: 10.1155/2018/5389282

Figure 4.

Figure 4

Increased proinflammatory cytokine secretion. Splenocytes derived from EAMG control, EAMG with NMO-Ig, and from naive mice injected with NMO-Ig or AQP4 peptide, or CFA, was activated by anti-CD3. Cell-free supernatants were tested for the cytokine content by specific ELISA. IFNγ was tested after 24 h of stimulation, IL-6 (48 h of stimulation), and IL-10 (after 72 h). Results are the mean of 2 different sets of experiments of 3–5 mice in each group and are expressed as the mean ± SE. ∗P < 0.05 compared to CFA-injected mice.