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Aggravation of clinical severity and muscle strength in EAMG and naive mice by immunization with AQP4 peptide and NMO-IgG.
| EAMG control | EAMG + NMO-IgG | EAMG + AQP4 peptide | Naive + NMO-IgG | Naive + AQP4 peptide | Naive | |
|---|---|---|---|---|---|---|
| Mean severity | 0.624 ± 0.01 | 0.82 ± 0.01 | 1.5 ± 0.02∗ | 0.72 ± 0.01 | 0.63 ± 0.02 | 0 |
| Gram force | 242.8 ± 4.5 | 214.3 ± 4.5∗ | 219.4 ± 5.6∗ | 227.7 ± 8.9∗∗ | 219.6 ± 5.4∗∗ | 307.9 ± 7.4 |
| Decrease in force (versus naive) | 21.13% | 30.40% | 28.73% | 26.03% | 28.73% | 0 |
∗ versus EAMG control. ∗∗ versus naive.
