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. Author manuscript; available in PMC: 2018 Jun 5.
Published in final edited form as: Cell Rep. 2018 May 8;23(6):1651–1664. doi: 10.1016/j.celrep.2018.04.016

Figure 6. Expression Profile of CDK5 and Stem Cell Genes Segregate in Non-mesen-chymal GBMs.

Figure 6

(A) Using TCGA RNA-seq RSEM data, we examined whether the expression of CDK5, CDKR1, and CREB1, along with the self-renewal and asymmetric cell division marker genes, have a clinical significance. Unsupervised hierarchical clustering analysis indeed show that a majority of the non-mesenchymal GBMs (cluster 1) express high levels of these genes, whereas mesenchymal GBMs have high expression of differentiation markers (cluster 2).

(B) Our detailed analysis showed that 62.96% of non-mesenchymal tumors fall in cluster 1 (p < 0.001), whereas ~83.33% of mesenchymal tumors fall in cluster 2 (p < 0.001).