Table 2.
Serum profile of zebrafish after consumption of high cholesterol diet and ketohexose for 3 weeks.
| ND1
(n = 70) |
HCD2
(n = 70) |
HCHF3
(n = 70) |
HCHT4
(n = 70) |
|
|---|---|---|---|---|
| Weight (mg)/height (mm) | 9.2 ± 1.6 | 9.9 ± 2.0∗ | 8.9 ± 1.5 | 9.3 ± 1.9 |
| Total cholesterol (mg/dL) | 108 ± 5 | 385 ± 15∗∗ | 330 ± 2∗∗ | 407 ± 34∗∗ |
| Tricylglyceride (mg/dL) | 232 ± 10 | 271 ± 51∗∗ | 311 ± 31∗∗ | 194 ± 13∗∗ |
| Glucose (mg/dL) | 54 ± 16 | 73 ± 18∗∗ | 105 ± 25∗∗ | 83 ± 26∗∗ |
| GOT (Karmen/mL) | 178 ± 4 | 221 ± 31∗∗ | 271 ± 27∗∗ | 191 ± 17∗∗ |
| CETP activity (% CE-transfer/4 h) | 37 ± 1 | 48 ± 6∗∗ | 49 ± 1∗∗ | 42 ± 0∗∗ |
1ND: normal diet, Tetrabit®: Tetrabit (47.5% crude protein, 6.5% crude fat, 2.0% crude fiber, 10.5% crude ash, containing vitamin A [29,770 IU/kg], vitamin D3 [1860 IU/kg], vitamin E [200 mg/kg], and vitamin C [137 mg/kg]). 2HC: high cholesterol (4% cholesterol in ND, wt/wt). 3HCHF: high cholesterol and high fructose (50% fructose in HCD, wt/wt). 4HCHT: high cholesterol and high tagatose (50% tagatose in HCD, wt/wt). Data were analyzed by ANOVA Bonferroni t-test. Levels of significance were represented in the form of ∗∗ P < 0.001, ∗ P < 0.05 when compared with initial (ND) group. TC: total cholesterol; TG: triglycerides; GOT: glutamate oxaloacetate transaminase; CETP: cholesteryl ester transfer protein.