Fig. 2.

Functional annotations of phosphoites across age groups. (a) The known-functional and polymorphic sites in disordered regions were differently distributed among the three age groups for human and mouse. The functional phosphosites were more likely to be older and polymorphic sites were more likely to be younger (p-value< 0.01, Chi-squared test). (b) The proportion of age groups in disordered regions varied between BFMs and VFMs. In both human and mouse, young phosphosites occupied larger proportion in the BFMs than the VFMs (p-value = 0.035 and p-value< 0.01, separately, Chi-squared test). BFMs: basic functional modules; VFMs: vertebrate-specific functional modules