Table 2.
Immunological features of EIgM and NIgM patients
| Parametera | EIgM N = 15 |
NIgM N = 31 |
p |
|---|---|---|---|
| WBC (K/mL) | 8.8 ± 1.6 | 8 ± 2.9 | p = 0.16 |
| ANC (K/ml) | 5.6 ± 1.3 | 5.2 ± 2.5 | p = 0.3 |
| ALC (K/ml) | 1.7 ± 0.5 | 1.9 ± 0.8 | p = 0.25 |
| CD3 + (K/ml) | 1042 ± 526 | 959 ± 511 | p = 0.33 |
| CD4 + (K/ml) | 466 ± 236 | 839 ± 1797 | p = 0.25 |
| CD8 + (K/ml) | 597 ± 433 | 443 ± 247 | p = 0.09 |
| CD20 + (K/ml) | 145 ± 67 | 167 ± 185 | p = 0.36 |
| CD56+ (K/ml) | 26 ± 10 | 23 ± 10.7 | p = 0.24 |
| Patients treated with IVIG | 10/13(77) | 14/27(52) | p = 0.13 |
| Age at IVIG initiation (years) | 9.4 ± 5.7 | 6.6 ± 3.7 | p = 0.09 |
| Average IgA (mg/dL) | 82 ± 97 | 59.5 ± 81 | p = 0.22 |
| C3(mg/dL) | 146 ± 30.4 | 144.1 ± 11.3 | p = 0.46 |
| C4(mg/dL) | 27 ± 8 | 37.4 ± 1.8 | p = 0.06 |
| KREC-CJ | 732 ± 390 | 2568 ± 3115 | p = 0.033 |
| KREC-SJ | 22 ± 17 | 112 ± 199 | p = 0.08 |
| TREC | 13.9 ± 8.2 | 64.2 ± 93.5 | p = 0.046 |
| Normal lymphocyte proliferation | 6/9(67) | 19/23(83) | p = 0.33 |
WBC white blood cells, ANC Absolute neutrophil count, ALC absolute lymphocyte count, IVIg Intravenous immune globulin, C Complement, NK Natural Killer cell, TREC T cell receptor excision circle, KREC kappa-deleting recombination excision circles (CJ ψJα coding joint, SJ ψJα signal joint)
aContinuous variables are presented as mean ± SD. Categorical variables are presented as N (%)