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. 2018 Jun 4;15:174. doi: 10.1186/s12974-018-1212-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A time line of the experimental protocol. Stroke was induced in all mice via the middle cerebral artery occlusion (MCAO). All mice were scanned by MRI at day 2 after MCAO. MSCs or IL13-MSCs were transplanted into the right hemisphere, ipsilateral to the lesion, after performing MRI. Motor and sensory performance were tested and ranked according to the modified neurological deficit scores (mNDS), once before MCAO (baseline) and every 2 days after MCAO until the day of perfusion. All animals were sacrificed at day 14 after MCAO induction. Abbreviations: B = behavior, MCAO = middle cerebral artery occlusion, MRI = magnetic resonance imaging, IHC = immunohistochemistry