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Pertussis toxin and YM-254890attenuate propionic acid-mediated t-PA induction in NHBE cells. Submerged NHBE cells were pretreated with PTX or PBS (A), YM-254890 or DMSO (B), PTX (1 ng/mL) and YM-254890 (1000 nmol/L) (C) (n = 5) prior to stimulation with 10 mmol/L of propionic acid for 24 h. Cell lysates were harvested for RNA extraction to analyse t-PA mRNA expression by RT-PCR. Data shown are mean ± SEM of independent experiments. *P < .05, **P < .01, ***P < .001
