Fig. 1.

Prediction of TF targets with OC-SVM. TF binding motifs were scanned along promoter regions (-10kb~+10kb around TSS) for annotated genes. Co-expression between TF and candidate targets, as well as between the TF PPI neighborhood and candidate targets, were analyzed. An OC-SVM model was trained with curated TF-target knowledge, and synthetic negatives were used for evaluating its performance