Fig. 4.

Transcriptional hallmarks for LUSC. a Consistency of up-regulated TFs identified in the LUSC and LUSC2 datasets. b Clustering of up-regulated TFs shared in the two LUSC datasets. TFs with 10 or fewer targets shared between the two datasets have been filtered out before clustering. Cluster membership was determined using Fisher’s exact test (p<0.05). c, d Expression patterns of the TP63/SOX2/DMRT3 module and their commonly regulated genes in LUSC (c) and LUSC2 (d) datasets. e Functional enrichment of co-regulated genes by TP63/SOX2/DMRT3 (left). A hypothetical regulatory model was proposed (right)