Table 5.
Significant pathways for DEGs associated with the intake main effect identified using IPA
| Pathway | P-valuea | DEGs in Pathway |
|---|---|---|
| 4-hydroxyproline degradation I | 0.00803 | HOGA1 |
| Methylglyoxal degradation I | 0.012 | HAGHL |
| D-glucuronate degradation I | 0.012 | DCXR |
| Glycerol-3-phosphate shuttle | 0.016 | GPD1 |
| Arginine degradation I (arginase pathway) | 0.016 | OAT |
| Arginine biosynthesis IV | 0.0239 | OAT |
| Proline biosynthesis II (from arginine) | 0.0239 | OAT |
| Arginine degradation VI (arginase 2 pathway) | 0.0239 | OAT |
| Glycerol degradation I | 0.0239 | GPD1 |
| CNTF signaling | 0.0267 | CNTFR, HRAS |
| Citrulline biosynthesis | 0.0318 | OAT |
| PPARa/RXRa activation | 0.0362 | CHD5, GPD1, HRAS |
aCorrected for multiple testing using Benjamini Hochberg method