Fig. 1.

Disease manifestations and signs and symptoms in the overall population. Prevalence and median age at onset of (a) organ system involvement (n = 56) and (b) signs and symptoms present in more than 70% of patients in the overall population. The overall population contains both prospective and retrospective patients. Diamonds represent the median age of onset (years). Error bars indicate the 10th and 90th percentiles. Patient numbers for median age at onset of organ system involvement (n = 11–53) and signs and symptoms (n = 33–53) may differ from those for prevalence due to data available in the Hunter Outcome Survey. MPS II, mucopolysaccharidosis type II