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. 2018 Jun 4;217(6):1957–1972. doi: 10.1083/jcb.201611087

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© 2018 Bobkov et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 7. — Two-step model for assembly of new dCENP-A at centromeres. (A) Table summarizing the data concerning the centromeric localization of proteins tested in Figs. 3 and 6. (B) Putative model for the assembly of new dCENP-A at centromere: (1) CAL1-targeted new dCENP-A/H4 associates with centromeres, but incorporation is blocked by previously incorporated placeholder nucleosomes; and (2) FACT-mediated transcription induces the eviction of nucleosomes, thus allowing the full incorporation of new dCENP-A.