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. 2018 Jun 4;217(6):2033–2046. doi: 10.1083/jcb.201703205

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© 2018 Iuliano et al.

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Figure 3. — Myo1b overexpression induces multiple axon-like processes and requires the integrity of its PH motif. (A) Cortical neurons transfected with plasmids encoding EGFP, EGFP-Myo1b, and EGFP-Myo1b-K966A were immunolabeled for Tau-1 to identify nascent axons at DIV4 and analyzed by confocal microscopy. Representative z stacks are shown. Bars, 20 µm. (B) The percentages of neurons with none, single, or multiple axons were quantified after transfection of plasmids encoding EGFP, EGFP-Myo1b, and EGFP-Myo1b-K966A and immunolabeling at DIV4 for Tau-1. Data are shown as the mean of three independent experiments for each condition. Error bars represent ± SEM. n = 30 cells/experiment. Data distribution was assumed to be normal. χ² test. *, P < 0.05; ***, P < 0.001.