Table 1. Effects of RNAi knockdown of C. elegans cargo receptor homologs in VIT-2 secretion from the intestine.

C. elegans	S. cerevisiae	Mammals	Identified cargo proteins (species)	VIT-2 accumulation in the intestine
ile-1	Emp46p/Emp47p	ERGIC-53	Coagulation factors V and VIII, Cathepsin C and Z, α1-antitrypsin (Hs)	−
sel-9	Emp24p	p24β	Gas1p (Sc)	−
rer-1	Rer1p	Rer1	Sec12p, Sec63p, Sec71p, Mns1p (Sc)	−
sft-4	Erv29p	Surf4	gp-α-factor, CPY, proteinase A (Sc)	+++

Hs, Homo sapiens; Sc, Saccharomyces cerevisiae.