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. 2018 Jun 4;217(6):2005–2018. doi: 10.1083/jcb.201708137

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© 2018 Wang et al.

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Figure 8. — Muscle-specific knockdown of BAF promotes increased DNA content in myonuclei. Representative image of muscle 7 of control (Mef2-GAL4/yw, A–C) or after muscle-specific knockdown of BAF (Mef2-GAL4>BAF RNAi, D–F), labeled with phalloidin (red, A and D), lamin C (green, A and D; white, B and E) and Hoechst (blue, A and D; white, C and F). (G) Quantification of Hoechst integrated density (averaged per myofiber) in the two groups indicates a significant increase of Hoechst integrated density after knockdown of BAF (***, P = 0.0001; control, n = 13; BAF RNAi, n = 15). (H) Quantification of lamin C integrated density (averaged per myofiber) in the two groups indicates a significant increase of lamin C fluorescence after knockdown of BAF (****, P = 7.4 × 10⁻⁶; control, n = 13; BAF RNAi, n = 15). Whiskers extend to data points less than 1.5 interquartile ranges from the first and third quartiles. Bar, 10 µm.