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. 2017 Jun 20;31(10):4305–4324. doi: 10.1096/fj.201700097R

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Figure 4. — A–D) Immunoreactivity of VEGF-A/C, CD31, and vWF was increased in liver sections from Mdr2^−/− compared with normal WT mice, and enhanced mRNA expression of Vegf-a/c, Vegfr-2/3, Angpt1/2, Tie-1/2, Cd31, and vWF in total liver and Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2 in cholangiocytes from Mdr2^−/− compared with WT mice. Exposure of Mdr2^−/− mice to darkness or melatonin treatment decreased the expression of VEGF-A/C, CD31, and vWF in liver sections (A, B), and Vegf-a/c, Vegfr-2/3, Angpt1/2, Tie-1/2, Cd31, and vWF in the selected samples compared with Mdr2^−/− mice (C, D). Original magnification, ×40. E) Immunoreactivity for vWF was enhanced in liver sections from 1 patient with late-stage PSC compared with 1 healthy control, and mRNA expression of VEGF-A/C, VEGFR-2/3, ANGPT1/2, TIE-1/2, CD31, and vWF was increased in human late-stage PSC samples compared with control samples. Original magnification, ×40. Data are means ± sem of 3 PCR reactions from 4 different samples obtained from 4 healthy male control subjects and 4 male patients with PSC. *P < 0.05 vs. control samples.

Figure 4. — A–D) Immunoreactivity of VEGF-A/C, CD31, and vWF was increased in liver sections from Mdr2^−/− compared with normal WT mice, and enhanced mRNA expression of Vegf-a/c, Vegfr-2/3, Angpt1/2, Tie-1/2, Cd31, and vWF in total liver and Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2 in cholangiocytes from Mdr2^−/− compared with WT mice. Exposure of Mdr2^−/− mice to darkness or melatonin treatment decreased the expression of VEGF-A/C, CD31, and vWF in liver sections (A, B), and Vegf-a/c, Vegfr-2/3, Angpt1/2, Tie-1/2, Cd31, and vWF in the selected samples compared with Mdr2^−/− mice (C, D). Original magnification, ×40. E) Immunoreactivity for vWF was enhanced in liver sections from 1 patient with late-stage PSC compared with 1 healthy control, and mRNA expression of VEGF-A/C, VEGFR-2/3, ANGPT1/2, TIE-1/2, CD31, and vWF was increased in human late-stage PSC samples compared with control samples. Original magnification, ×40. Data are means ± sem of 3 PCR reactions from 4 different samples obtained from 4 healthy male control subjects and 4 male patients with PSC. *P < 0.05 vs. control samples.