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. 2017 Jun 20;31(10):4305–4324. doi: 10.1096/fj.201700097R

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Figure 6. — A) Treatment of Mdr2^−/− mice with an miR-200b inhibitor decreased the expression of miR-200b in total liver. B) IBDM (original magnification, ×25) and Pcna mRNA expression decreased in isolated cholangiocytes. C–E) Liver fibrosis (C) and immunoreactivity for COL1A1 and Fn-1 (D) decreased in liver sections, as did the expression of Col1a1 and Fn-1 in total liver samples and in isolated cholangiocytes and stellate cells (E). F, G) The immunoreactivity for CD31 and vWF in liver sections (F) and the expression of Vegf-a/c, Vegfr-2/3, Angpt1/2, Tie-1/2, Cd31, and vWF in total liver and Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2 in cholangiocytes (G) decreased compared with levels in control mice. Data are means ± sem of 6 evaluations in total liver samples collected from 6 separate animals; of 3 evaluations in cholangiocytes collected from 2 cumulative preparations from 3 mice (n = 6 mice); and of 6 evaluations of LCD-isolated stellate cells from 3 individual mice. *P < 0.05 vs. vehicle-treated Mdr2^−/− mice.

Figure 6. — A) Treatment of Mdr2^−/− mice with an miR-200b inhibitor decreased the expression of miR-200b in total liver. B) IBDM (original magnification, ×25) and Pcna mRNA expression decreased in isolated cholangiocytes. C–E) Liver fibrosis (C) and immunoreactivity for COL1A1 and Fn-1 (D) decreased in liver sections, as did the expression of Col1a1 and Fn-1 in total liver samples and in isolated cholangiocytes and stellate cells (E). F, G) The immunoreactivity for CD31 and vWF in liver sections (F) and the expression of Vegf-a/c, Vegfr-2/3, Angpt1/2, Tie-1/2, Cd31, and vWF in total liver and Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2 in cholangiocytes (G) decreased compared with levels in control mice. Data are means ± sem of 6 evaluations in total liver samples collected from 6 separate animals; of 3 evaluations in cholangiocytes collected from 2 cumulative preparations from 3 mice (n = 6 mice); and of 6 evaluations of LCD-isolated stellate cells from 3 individual mice. *P < 0.05 vs. vehicle-treated Mdr2^−/− mice.