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. 2017 Jun 20;31(10):4305–4324. doi: 10.1096/fj.201700097R

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Figure 7. — A) In IMCLs stably trasfected with AANAT, Aanat mRNA expression and melatonin levels were enhanced in cholangiocyte supernatant but decreased expression of miR-200b, Col1a1, Fn-1, Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2. Data are means ± sem of 3 evaluations from 3 individual preparations of biliary cell lines. *P < 0.05 vs. Neg. B, C) Treatment with a miR-200b inhibitor decreased the expression of Col1a1, Fn-1, Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2 in IMCLs (B) and the expression of COL1A1 and FN-1 in HHSteCs (C). Data are means ± sem of 3 evaluations from 3 individual preparations of cholangiocyte or stellate lines. *P < 0.05 vs. control cell lines. D) When HHSteCs were treated with supernatant from IMCLs treated with miR-200b inhibitor, expression of COL1A1 and Fn-1 was decreased compared with HHSteCs treated with control IMCL. Data are means ± sem of 3 evaluations from 3 individual preparations of IMCLs. *P < 0.05 vs. stellate cells treated with control cholangiocyte supernatant.

Figure 7. — A) In IMCLs stably trasfected with AANAT, Aanat mRNA expression and melatonin levels were enhanced in cholangiocyte supernatant but decreased expression of miR-200b, Col1a1, Fn-1, Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2. Data are means ± sem of 3 evaluations from 3 individual preparations of biliary cell lines. *P < 0.05 vs. Neg. B, C) Treatment with a miR-200b inhibitor decreased the expression of Col1a1, Fn-1, Vegf-a/c, Vegfr-2/3, Angpt1/2, and Tie-1/2 in IMCLs (B) and the expression of COL1A1 and FN-1 in HHSteCs (C). Data are means ± sem of 3 evaluations from 3 individual preparations of cholangiocyte or stellate lines. *P < 0.05 vs. control cell lines. D) When HHSteCs were treated with supernatant from IMCLs treated with miR-200b inhibitor, expression of COL1A1 and Fn-1 was decreased compared with HHSteCs treated with control IMCL. Data are means ± sem of 3 evaluations from 3 individual preparations of IMCLs. *P < 0.05 vs. stellate cells treated with control cholangiocyte supernatant.