Table 3.

Grading of the common neurotoxicity symptoms

Neurotoxicity grading assessment (CTCAE 4.03)	Grade 1	Grade 2	Grade 3	Grade 4
Encephalopathy	Mild limiting of ADL	Limiting instrumental ADL	Limiting self-care ADLs	Life-threatening consequences
Confusion	Mild disorientation	Moderate disorientation; limiting instrumental ADL	Severe disorientation; limiting self-care ADL	Life-threatening consequences; urgent intervention indicated
Dysphasia	Awareness of receptive or expressive characteristics; impaired ability to communicate	Moderate receptive/expressive characteristics; impaired ability to communicate spontaneously	Severe receptive/expressive characteristics; impaired ability to read, write or communicate intelligibly	N/A
Seizure	Brief partial seizure; no loss of consciousness	Brief generalized seizure	Multiple seizures despite medical intervention	Life-threatening; prolonged repetitive seizures
Somnolence	Mild, but more than usual drowsiness or sleepiness	Moderate sedation; limiting instrumental ADL	Obtundation or stupor	Life-threatening; urgent intervention indicated

Note: Neurotoxicity grading assessment of common adverse events from CAR T-cell therapy.

Abbreviations: ADL, activities of daily living; CAR, chimeric antigen receptor; CTCAE, Common Terminology Criteria for Adverse Events; N/A, not applicable.