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. 2018 May 31;11:3257–3265. doi: 10.2147/OTT.S165000

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© 2018 Xie et al. This work is published and licensed by Dove Medical Press Limited

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Single dose of Apa-MS but not Apa-Sol inhibited the in vivo growth of HCC cells and enhanced the effect of RFA on subcutaneous HCC model. The experimental animals were divided into the following groups: no-treatment group (negative control), solvent control group, Apa-Sol group, Apa-MS group, RFA group, RFA + solvent control group, RFA + Apa-Sol group and RFA + Apa-MS group. Results are shown as (A) photographs, (B) volume (mean ± SD, n = 8) and (C) weight of tumors (mean ± SD, n = 8). *P<0.05.

Abbreviations: Apa-MS, apatinib microcrystal formulation; Apa-Sol, apatinib solution; HCC, hepatocellular carcinoma; RFA, radiofrequency ablation.