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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Comp Biochem Physiol Part D Genomics Proteomics. 2018 Mar 22;26:40–49. doi: 10.1016/j.cbd.2018.03.004

Table 2.

Differentially Expressed Genes Involved in Major Pathways

JGID BLASTx Fold Change FDR p
Antioxidant
103340 Catalase (XP_001633745.1) −3.57 ↑ 2.10E-03
236349 Superoxide dismutase (XP_001641079.1) −7.68 ↑ 3.95E-09
89807 Thioredoxin (XP_001638442.1) −12.72 ↑ 5.42E-13
81388 Glutathione peroxidase (XP_001641220.1) −9.75 ↑ 1.21E-12
195315 HSP70 (XP_001622423.1)* −3.81 ↑ 1.32E-03
178640 HSP90 (X P_001640689.1) −6.16 ↑ 1.59E-06
Cell Cycle and Regulation
110405 PDZ binding protein (XP_001631518.1)* 2.24 ↓ 0.05
208897 Dynein light chain Tctex-type 1 (XP_001619966.1)* −3.08 ↑ 3.55E-04
185341 E3 ubiquitin-protein ligase MYLIP (XP_001633631.1)* −2.55 ↑ 6.75E-03
234384 Adenylate cyclase (XP_001637931.1)* −3.24 ↑ 3.27E-03
110258 Thrombospondin-1 (XP_001631080)* 4.79 ↓ 1.58E-06
98238 Homeobox protein (XP_001635465.1)* −2.63 ↑ 2.81E-03
86719 Astacin-like (XP_001639324.1)* 2.02 ↓ 0.04
114959 Wnt signaling protein (XP_001630030.1)* 2.04 ↓ 0.04
2028 Low-density lipoprotein receptor (XP_001623138.1)* 2.53 ↓ 0.03
Immunity
204961 RIPL1-like protein (XP_001634829.1)* −2.5 ↑ 0.04
170435 LBP (XP_001629157.1) −3.43 ↑ 6.33E-04
82163 MyD88 (XP_001641005.1) −8.64 ↑ 2.77E-09
1816 TIR (XP_001637587.1) −6.78 ↑ 5.44E-07
18 Complement (C3) precursor (BAH22723.1) −3.72 ↑ 7.22E-05
196263 MAC/PF (XP_001642092.1) −2.84 ↑ 3.57E-03
112390 TRAF6 (XP_001630936.1) 2.42 ↓ 0.01
Metabolism
248519 Malate dehydrogenase (XP_001622276.1) −23.45 ↑ 3.46E-14
186479 Carbonic anhydrase (XP_001632619.1) −3.48 ↑ 2.37E-03
244812 Fructose-bisphosphate aldolase (XP_001629735.1) −2.93 ↑ 6.27E-03
237552 Ferritin H (XP_001624357.1) −3.77 ↑ 0.02
173595 Glutamate transporter (XP_001625720.1) −3.44 ↑ 7.53E-04
Signal Transduction
50930 Melanopsin (XP_001631416.1)* 2.7 ↓ 8.63E-03
101020 HIOMT/melatonin (XP_001634470.1) −5.49 ↑ 5.18E-07
105524 RAS GTPase (XP_001633090.1)* −2.33 ↑ 6.93E-03
40487 Voltage-gated potassium channel (XP_001640129.1)* 2.69 ↓ 0.01
205216 Rhodopsin-like receptor (XP_001634610.1)* 2.24 ↓ 0.03
118227 Latrophilin receptor (XP_001620953.1) −2.78 ↑ 0.02
246569 Voltage-gated calcium channel (XP_001626501.1)* −2.13 ↑ 3.66E-03
88314 HIF1 (XP_001638872.1) −16 ↑ 5.83E-13
88486 CK1δ/ε (XP_001638852.1)* −2.25 ↑ 0.01
248021 bZIP CREB (XP_001623517.1) −7.83 ↑ 3.20E-08
242269 bZIP DNA Binding Site (XP_001634376.1) −20.78 ↑ 1.71E-15
150375 bZIP HLF (XP_001619763.1)* −4.71 ↑ 5.31E-05
Other
120351 Frataxin (XP_001628857.1)* −2.19 ↑ 2.27E-03
238195 TIMP (XP_001641336.1)* −3.34 ↑ 3.58E-03
*

Indicates maintenance of DE in the absence of a light cue.

The presented fold-change value represents mean expression at ZT18 minus ZT6 for each gene. Thus, a negative fold-change indicates higher expression during the daytime period of the 24-hour cycle, denoted by ↑.