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. Author manuscript; available in PMC: 2018 Jun 5.
Published in final edited form as: Cell Rep. 2018 May 1;23(5):1504–1515. doi: 10.1016/j.celrep.2018.03.135

Figure 6. Coordinated Phospho-regulation of Ste18 and Ste5 Evolved at the Same Time.

Figure 6

(A) Bootstrapped phylogenetic tree of Ste18 orthologs from the Ascomycota phylum showing the evolutionary co-occurrence of regulatory phosphorylation sites on the N-terminal tail of the Gγ subunit and the FBD of orthologous Ste5 scaffolds. The presence of Ste5 orthologous proteins, functional Ste5-like FBDs, and N-terminal Gγ phospho-regulatory intrinsically disordered regions (IDRs) are shown next to yeast species harboring each element.

(B) Species that contain the synergistic regulatory element (Ste18Nt and Ste5FBD) are nearly 100% identical at phosphorylation site alignment positions in Ste18 and MAPK binding sites reported previously in Ste5 (Coyle et al., 2013).

See also Figure S7.