Table 2.

Main effect of group (healthy controls vs Alzheimer's disease) on phosphorus metabolite signals and tissue pH for all investigated regions.

	AD	Control	p-Value
PCr*	19.04 ± 0.18 n = 124	18.08 ± 0.18 n = 124	<0.001
Pi	5.30 ± 0.11 n = 121	5.47 ± 0.11 n = 123	0.240
PCr/Pi	3.71 ± 0.09 n = 121	3.49 ± 0.09 n = 123	0.046
total ATP	42.88 ± 0.27 n = 124	43.17 ± 0.27 n = 124	0.445
NAD(H)	3.96 ± 0.11 n = 103	4.09 ± 0.11 n = 96	0.388
PEth	8.19 ± 0.11 n = 119	8.33 ± 0.11 n = 122	0.375
PCh	3.90 ± 0.07 n = 112	3.93 ± 0.07 n = 114	0.757
GPEth	4.32 ± 0.11 n = 109	4.31 ± 0.11 n = 117	0.942
GPCh	5.96 ± 0.15 n = 108	6.08 ± 0.15 n = 109	0.526
pH	7.037 ± 0.003 n = 121	7.028 ± 0.003 n = 123	0.032

LS means ± SEM of metabolite levels, as percentage of total phosphorus signal in the corresponding spectrum, in patients with Alzheimer's disease and healthy control subjects. Significant group effects (p < 0.05, AD versus Control) indicated in bold. *PCr also has a significant interaction between group and brain region. LS, least squares; SEM, standard error of the mean; n, number of observations; AD, Alzheimer's disease; HC, healthy control; PCr, Phosphocreatine; Pi, inorganic phosphate; ATP, adenosine triphosphate; NAD(H), nicotinamide adenine dinucleotide; PEth, phosphoethanolamine; PCh, phosphocholine; GPEth, glycerophosphoethanolamine; GPCh, glycerophosphocholine.