Fig. 4.

DTI changes in the corpus callosum. (A) ADC template image for the female sham cohort and (B) magnified sections for each cohort showing reduced ADC in the corpus callosum following RmTBI. An ROI-based analysis of DTI metrics found that RmTBI rats had decreased (D) ADC, (F) AD, and (H) RD in the contralateral corpus callosum compared to shams (*p < 0.005). Although similar changes were seen in the ipsilateral corpus callosum (see C, E, G), these failed to reach statistical significance after Bonferroni correction. Bar graphs show mean + s.e.m.