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. 2018 Jun 1;13:3295–3310. doi: 10.2147/IJN.S158463

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© 2018 Shin et al. This work is published and licensed by Dove Medical Press Limited

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Inhibition of the proliferation of EJ bladder cancer cells by heterometallic Au@Pt-NSs.

Notes: Both EJ cells and HUCs were incubated for 24 h with different concentrations of Au@Pt-NSs (0, 0.1, 0.3, and 0.5 μM). Cell viability was measured using the MTT assay in EJ cells (A) and HUCs (D). Viable cells were measured using trypan blue staining for EJ cells (B) and HUCs (E). Morphological changes were observed after treatment with Au@Pt-NSs at different concentrations (0, 0.1, 0.3, and 0.5 μM) for EJ cells (C) and HUCs (F). For the bar graphs, values are presented as mean ± SD of three independent experiments; *P < 0.05, compared with the control group.

Abbreviations: Au@Pt-NSs, gold@platinum nanoseeds; Con, negative control; HUCs, human urothelial cells; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.