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. 2018 Jun 1;13:3263–3278. doi: 10.2147/IJN.S166021

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© 2018 Lee et al. This work is published and licensed by Dove Medical Press Limited

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In vivo antitumor efficacies in SKOV3-bearing BALB/c nude mice treated with different formulations.

Notes: Animals (n=5) received 10 mg DTX/kg intratumorally on day 0, 7, and 14, a total of three injections per mouse as indicated by arrows. (A) Changes in tumor volume for 6 weeks post-administration. (B) Body weight changes for 6 weeks post-administration. (C) Morphology of excised xenograft tumors at the end of the study (day 42). Black bar indicates 30 mm. Statistical analysis was performed using Student’s t-test (*P<0.05 versus saline; ^#P<0.05 versus DTX-Sol).

Abbreviations: DTX, docetaxel; DTX-Sol, docetaxel solution; DTX-NLC, docetaxel-loaded nanostructured lipid carrier; DTX-RIPL-NLC, docetaxel-loaded RIPL peptide-conjugated nanostructured lipid carrier.