Table 1.
Physicochemical characteristics of NLCs
| Characteristics | NLC | RIPL-NLC |
|---|---|---|
| Drug-free | ||
| Size (nm) | 154.63±6.15 | 232.57±26.26 |
| PDI | 0.270 | 0.294 |
| Zeta potential (mV) | −16.31±0.44 | 19.7±0.41 |
| DiI-loaded | ||
| Size (nm) | 166.93±8.30 | 269.63±7.92 |
| PDI | 0.232 | 0.319 |
| Zeta potential (mV) | −15.23±0.71 | 23.80±2.03 |
| DTX-loaded | ||
| Size (nm) | 184.73±6.48 | 240.83±3.44 |
| PDI | 0.193 | 0.265 |
| Zeta potential (mV) | −24.03±0.26 | 14.27±0.78 |
| Encapsulation efficiency (%) | 94.89±0.21 | 97.59±0.13 |
| Drug loading (µg/mg) | 44.2±0.10 | 45.9±0.20 |
Note: Data represent mean ± SD (n=3).
Abbreviations: DiI, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate; DTX, docetaxel; NLCs, nanostructured lipid carriers; PDI, polydispersity index; RIPL-NLC, RIPL peptide-conjugated NLC.