Table 2.
In vitro release kinetic parameters of various DTX formulations
| Formulations | Zero-order
|
First-order
|
Higuchi model
|
|||
|---|---|---|---|---|---|---|
| r2 | K0 | r2 | K1 | r2 | KH | |
| DTX-Sol | 0.8701 | 9.3674 | 0.9101 | 0.2036 | 0.8620 | 26.632 |
| DTX-NLC | 0.8320 | 1.2983 | 0.9772 | 0.0477 | 0.9797 | 11.979 |
| DTX-RIPL-NLC | 0.9381 | 1.4246 | 0.9725 | 0.0297 | 0.9764 | 11.833 |
Notes: K0, zero-order rate constant; K1, first-order rate constant; KH, Higuchi equation’s rate constant; r2, correlation coefficient.
Abbreviations: DTX, docetaxel; DTX-Sol, docetaxel solution; DTX-NLC, docetaxel-loaded nanostructured lipid carrier; DTX-RIPL-NLC, docetaxel-loaded RIPL peptide-conjugated nanostructured lipid carrier.