Table 1.

Renal impairment categories

Impairment	Estimated CLcr (mL/min)
Normal	≥90
Mild	60–89
Moderate	30–59
Severe	15–29
End-stage diseasea	<15 (not on dialysis) or requiring dialysis

Note:

^aNot observed in the TONADO^® studies due to the inclusion criteria.⁷

Abbreviation: CLcr, creatinine clearance (determined using the Cockcroft–Gault formula).