Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 4;150(6):883–889. doi: 10.1085/jgp.201711818

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — Concentration–response curves for Iso-induced Ca²⁺ currents in myocytes from WT, LCyphHET, and LCyphKO mice. Representative Ca²⁺ currents evoked by depolarization from −40 to 0 mV after treatment of dissociated cardiac myocytes with the indicated concentrations of Iso. (A) WT mice. (B) LCyphHET (HET) mice. (C) LCyphKO (KO) mice. (D) Mean maximal β-adrenergic–stimulated Ca²⁺ currents (calculated as Iso current/basal current and normalized for reduced expression of Ca_V1.2 in LCyphKO mice) at a test potential of 0 mV from WT, LCyphHET, and LCyphKO mice. Concentration–response curves were fit by a Hill equation with n_H = 1. The resulting estimates of concentrations that give a half-maximal response for stimulation by Iso were 34.4 nM in WT, 53.5 nM in LCyphHET, and 25.7 nM in LCyphKO mice. n = 4–8 cells for each data point; n = 8–10 mice of each genotype. WT, −8.73 ± 0.81 pA/pF; LCyphHET, −7.5 ± 1.3 pA/pF; LCyphKO, −4.9 ± 1.1 pA/pF; P < 0.05. **, P < 0.01. Error bars indicate SEM.