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. 2018 Jun 4;150(6):851–862. doi: 10.1085/jgp.201711968

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© 2018 Cherny et al.

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Figure 1. — Alignment of H_V1 S2–S3 linker and nearby regions (E153–D185 in hH_V1). H_V1 from several species were characterized as activating rapidly (green background: HtH_V1, LsH_V1, and SpH_V1) or slowly (pink background: hH_V1, mH_V1, OcH_V1, RrH_V1, and CgH_V1) based on available electrophysiological data. Unshaded species exhibit intermediate kinetics. In hH_V1 numbering, the asterisk (*) indicates the position corresponding to the throttle histidine H168; the caret (^) indicates the position corresponding to F165. The S2–S3 linker in hH_V1 encompasses K157–F165 (Li et al., 2015).