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The Q229H mutation does not restore human-like activation kinetics or pHi sensitivity to HtHV1. (A–D) Families of currents in an inside-out patch with pHo 7 in the pipette solution in 10-mV increments up to the voltage shown from Vhold = −80, −60, −40, and −40 mV, at pHi 5, 6, 7, and 8, respectively. (E) Currents from this patch converted to gH produce gH-V relationships that shift much less than 40 mV/unit. Corresponding measurements in WT HtHV1 are plotted in Fig. 5 G.
